Interested Article - COVID-19

COVID-19 ( ????. ?? ????. CO rona VI rus D isease 20 19 — ??????????????? ????????? 2019 ???? , ???. ?????? ), ????? ?????????????? ???????? 2019-nCoV — ???????????? ??????? ?????? ????????????? ???????? , ?????????? ????????????? SARS-CoV-2 (2019-nCoV) . ???????????? ????? ??????? ??????????? , ??????? ????? ????????? ??? ? ????? ?????? ????????????? ???????? ???????? ??????? ??????? , ??? ? ? ??????? ????? . ? ???????? ???????????????? ????????? ??????????? ????????? ?????????? ??????????? ????, ???????????? ? ????? ?????? . ????? ???????? ???????? ????????? ?????? ????? ?????? ????????????? ??? ??????????? ????????? ?????? ????????? . ???????? ?????? ??????????? ??????????? ???????? ???????? ????????? , ????????? ????????? ? ??????? ?????????????? ????????-???????? ? ??????????? ?????? ??????????? ??????????????? , ??? ??????? ???? ????? ?????????? ??????????? ??????? ? ????????????? ????????? . ? ????? ?????????? ?????? ???????????? ??????????????? , ??????????? ??? ? ???????? ????????????? .

???????????????? ????? ????????-????????? ????? ????? ???????? ??????????? ? ??????? ??? ?????, ??????? ??? ????????? ?????? ? ???????, ? ????? ????? ????????? ?????? ?? ??????????? ? ??????????? ?????????? ? ?????, ??? ??? ???. ???????? ????????? ?????????????? ??????????????? ???????? ???????? ????? , ?????? ??? ?????? ??????????? ?????? ? ?????????? ?????? ??? ????????????, ??????? ?????????? ?????????? ????????? ? ????????? ?????????? ? ????????? ????????????? ? ??????? ??????????? ????? . ? ????? ??????????? ??? ???????????? ????????? ?????? ????? ??? ? ?????????? ?????? ????????????? ??????? .

?????????? ???????? ?????????? ? ??????????? ???????? ???????? ??????: ?????? ?? ???????????, ???????? ???????, ???????????????? ??????? ? ????????????? ????? ???????? . ??????? ???????? ????????? ????? ????????? ?????? ? ????????????, ?? ??????????? ?????????? ?? ????????, ??? ????? ???????????? ???????????? ?????? ???????????? , ????????? ?????????? ? ?????? ??????? ?????????? ?? ?????? ?? ???????????, ? ?? ?? ???????? . ????? ?????????? ?????? ????? ????????? ??????????????? ?????? ???????? ???????, ????? ??????? ???????? ????, ???? ? ??????, ????? ? ????????? ??????????? .

? ??????????? ???????????? ???????? ????????? ? ?????? ????? ??? ???????????? . ???????? ? 80 % ?????-???? ????????????? ??????? ?? ?????????, ? ????????????? ?????????? ???? ?? ???? . ???????? ? 15 % ??????? ??????????? ????????? ? ??????? ????? ? ?????????????? ?????????? ??????????? ??????? , ??? ? 5 % ????????? ??????? ??????????? . ?????? ?????? ??????????, ??? ???????-????? ???????? ????? ??????? ????????, ?????? ?????????? ???????? . ? ?????? ??????? ????????? ??????? ????? ? ??????????, ????????????????, ????? ????????? ? ???????? ??????????????? ???????? . ????? ???????? ???????????? ???????????, ?????????? ???????????? ????????? .

??????? ????? ??????? ? ??????? ???????????? ????? ????????? ? ??????? ????? ? ? ????? ? ????????????? ?????????????? ?????????????, ??????????? ????? , ?????? ? ????????? ??????????? . ??????? ?????????? ?? ??????????? ????? ??????????? ???, ??? ??? ????? ???????? ?????? ??????, ??????? ?????? , ?????? , ????? ? ?????? , ?? ???? ?? ??????? ????? ????????? ????????????? ??????? . ? ??????? ??? ??????????? ??????? ????????? ??????????? ??????????????? (???) ??????????? ????????? ??????????????? ? ??????????? (????????? ????-?????) . ? ??????? ??????? ????? ??????????? ???????? ??? ??????????? ??????? ???????? ?????? ??????? .

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31 ??????? 2019 ???? ????????? ??????????? ??????????????? ???? ???????????????? ?? ??????????? ??????? ?????????, ????????? ??????????? ????????????, 3 ?????? ????????? ?????? ???????? ??? ? 44 ??????? ????????? ? ?????? ????? ????????? ????? . ??????? ???????? ????? ????????????? (???? ????????? ??? SARS-CoV-2, ????? — ??? ????????? ????????? 2019-nCoV ), ??????? ????? ?? ????????????? ????? ???????????? ????????? . 30 ?????? 2020 ???? ? ????? ?? ???????? ???????? ??? ???????? ???????????? ???????? ?????????????? ???????? ? ??????? ??????????????? , ? 28 ??????? 2020 ???? ??? ???????? ?????? ?????? ?? ?????????? ?????? ? ??????? ?? ????? ??????? . 11 ????? 2020 ???? ???????? ???? ???????? ????????? . ???????? ?????? ???, ??? ????????????? ??????????? ????????? ????????? ????? ????? ???????? ? ??????????????? ??????? ??????????????? ? ?????????? ??????????? ?????????????? ? ????????? ??????? . ??????? ??????????????? ????? ????????? ?? ?????? ? ?????????? ???????? ?????????? ????????????? ????????? . ???????? ?????? ???????? ????? ?? ????????? ? ???????? ???????? ?? ???????? ???????????, ? ???????? ???????? ?? ??????????????? , ????? ????????? ?? ?? ??????? ? ???????, ????? ???????, ???????? ?? ??????? ??????????????? . ???????? ??????????, ??? ?????? ????? ????????? ???????????? ??????????? ???????????? ????????? . ??? ?? ?????, ???????? ????????, ?? ???????? ????? ?????? ???? ????? ????? ?????? ???? ? ????? ?????????????? ? ?????? ??? ?????? ????? .

??????????? ?????????? ???? ???? ?????????, ????????? ?? ??????? ????? ? ????????? SARS-CoV-2 ?????????? 50 ???. ??????? ????? ??????????? ???? ?????? ? ??????? ????? ????????? ?? 60 ??? ? ?????????????? ?????????????. ??????????? ??????? ????? ? ????? ????????? ??????????? ? ?????? ?????, ? ??? ????? ? ???? ?????? ?????????, ??? ???????????????? .

? ????????? ?????? ? ??????????? ?? 72 314 ??????? ??????????? ? 81 % ??????? ??????????? ????????? ? ?????? ?????, ? 14 % — ? ??????? ? ? 5 % ????????? ????????? ???? ??????????? .

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?????????????? ??????????? COVID-19 ?????????? ????? ??????????? ????????????????? SARS-CoV-2, ??????? ??? ????????? ? ???????? ????????, ?????? ?? ?????? ? ?????? ????????? ? ?????????? ? ????????? ?????? ????? ? ??????? 2019 ????. SARS-CoV-2 ????????? ? ??????? Sarbecovirus ? ???????? ??????? ?? ????? ????????? ?????????????, ????????? ???????? ???????? .

SARS-CoV-2 ???????? ???-?????????? ??????? ? ????????? . ?? ????????? ???????????? ????????? ????????, ??? ????? ???????? ??????????? ???????????? ???????????? ??????? ????? ? ??????, ???? ??? ?? ?????????, ?????????????. ??????????????, ??? ???????? ????? ????????? ?? ????????? . ?????????????? ????? ????? ????????? ?????? SARS-CoV-2 ??????????? ????????? ???????? ? ??????, ????????????? ? ?????????? . ?????? ????? ?????? ???????????, ????????? ? ???????? ??????? ? ???????? ? ??? ????? ????? ???? GenBank .

?? ???? ????? ???????? ? ?????? ?????????? ???????????? ??????? ? ??????????? ????? ???????????? ?????????, ?????? ???????????? ?????? ???????????? ?????????. ????????? ??????? ????? ??????????? ?? ???????? ??????????????? ??????, ?? ??????? ??????????? ?? ??????????? ??? ?? ????????????? ??? ??? ???? ??????? ??????? . ?????? ? ?????? ????????? ???????? «??????????» ?????? ??? ???????? . ??? ???? ?? ??? ???????? ???????? ????????, ????? ?????? ??????????, ???? ? ???????? ?????? ?????????? ?????????? ???????? .

? ???????????? ? ??????????????, ???????????? ???, ?????????? ???????? ???????? ???????????? SARS-CoV-2 ??????? ??????? ?????????? ???????? . ?? ????????? ?? ?????? 2021 ???? ???????? ?????? : ????? , ???? , ?????? , ????? ? ??????? .

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????? ?????????? ????????-????????? ????? ????? ???????? ?????? ??????, ??????????? ? ??????? ??? ?????, ??????? ??? ????????? . ????? ? ??????? ????? ???????? ?? ??????????? ? ????????, ? ????? ???????????? ??????????????? ? ??? ???????? ????? ??????????? ????????????? ? ??????, ???? ??? ??? . ????? ????? ?????????? ?????????????? ? ??????? ?????????? ?????, ??????? ?? ??????????? ?????????. ?? ???????? ???????????? ? ?? ???????? ?? ????? ??????????? ?? 2—3 ???? . ???????????? ? ??????? ??????????? ????????, ??? ????? ??? ?? ?????????? ? ??????? ?? ?????????? ?????, ?????? ??? ????????, ??? ? ???????????? ? ??????????? ???????? ?????????? ?????????? ???? ????????, ? ? ???????? ?????? ?? ??????? ???? ?? ?????????? . ???? ?????????????? ????? ????? ??????????? ? ?????????? ????????, ??? ?????-???? ????????????? ??????????? ????????? ????????-???????? ????? . ???? ????? ????????? ? ???, ??? ????? ????????????? ? ????? ? ????? .

????????? ???????? ?????????????????, ??????????????????? ? ???????????????? ??????????????. ???????? ???????? ????????? ?????? ????????? ?? ???????? ????????? ? ?? ?????? ?????? ??????????? . ?? ???? ??????????????????? ?????????????? ????? ??????????? ????? ???????? ???? ??????? ???????? ???????? . ??? ???????? ????????????????? ??????????????, ???? ?????????, ????????? ???????? ???? ??????????? ???????? ???????? ? ?????? ?????? . ?????? ???????? ?????????? ???????????? ?????????? ???? ???????????????? ???????, ? ?????????? ???? ???? ????????????????? ???????? ? ???????? ????? ???????? .

???? ????????? ? ???????? ???????? ?? ???????? ???????? ?????? , ?????? ? ?????. ???????????????? ????????, ??? ????? ????? ????? ???????????? ????? ????????? ???????. ??????????? ???????? ?? ????? ? ???????? ??????? ?????????? ???????????? .

???????????????? ????? ??????????? ?????????? ? ????? ? ???????? ????????, ? ????? ? ??????????? ? ??????? ?????????? ??????????. ???? ???? ???? ????????? ????????????? ? ?????? ?????? ?????????? ? ???????? ????????? . ?????? ?????? ?????????????? ?????? ????? ?????????????????? ??????????? ? ????????? ??????????????? ???????? ? ????????? ??????? ?? ?????? ??????????? ???????? ??????????????? ? ???????????? ?????????? ????? .

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????? ????????? ? ??????????? ???? ????????? ???????? ?????? ?????????? ????????????? ?????? ??????????? ?????, ???????????? ????????????? ?????? ? ?????????????? ?????? ??????? . ????? ???????? ? ?????? ?????????????? ????? ????????? ? ????????? — ???????????????????????? ???????? 2 (???2) ?????? . ???? ?? ????? ??????????? ????????????? ? ?????? ?????? SARS-CoV , ?????? ??????????? 3D-?????? ????????? ?? ??????????? ?????? ? ?????? SARS-CoV-2 ???????????? ???????? ????? ??????? ?????????????? ? ?????????? . ????? ? ?????? ????? ???????????? ??????????????? ???????????? ????????? ??????? , ??????? ????????????? ? ?????? SARS-CoV . ????? ????????????? ? ????????? ????? SARS-CoV-2 ?????????? ????????? ?????? ? ???????? ??? ?????????????. ???????? ????????????? ??????????????? ????????? ???????? 2 ( TMPRSS2 ) .

????? ????????? ?????? ? ??? ? ??????? ?????????? ???? ?????????? ????????? ?????????? ?????? ? ??? ??????????????? ?? ???????????? ??????????? ?????, ?? ???? ????? ???????? ????????? ???????????? ? ???????????? ???????? ???????, ?? ??????? ???????? ????????, ? ????? ?????????????? ???????? ????? ?? ????. ????? ?????????? ??????????????? ???????? ?? ????????? ????? ??????? ??????????? ?????, ? ?????????? ???? ????? ?????????? ???????? ?????????, ??????????? ? ?????? ?????. ?? ???? ????? ?????????????? ?????? ???????????? (????.) ( , ??????????? ???? ? ?????, ? ????????? ?????? ????? ??????? ??? ?????????????? ??????????? ??????????????? ????????, ??? ?????????? ? ??????????? ?????????? . ?????????? ????????? ???????? ????? (????? CD4+ ? CD8+ T-??????) ????????????? ? ????? ?????? ???????? ??????????? . ? ???????? ????? ????? ?????????? ???????? ???????????????? ?? ?????? ??????????? ???? ? ????????? ????? ??????? ????????? . ??? ???? ?? ????????? ? ??????? ???????? ???????????? ?????????, ???????? ???????? ???? ?? ?????? ??????? ????????, ?? ???????????? ??????????? ? ????? ?? ??????????? ??????, ???????? ???? ???? ?????????? . ?????????? ? ????????? ?????????????? ????? ???????? ????????????? ????????? ??????????? ?????????, ?????? ? ??????? ??????? ??? ????? ?????????? ??????????? .

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

?????? ????????? ?????? ??????????? ??????? ? ??????? ????? ??????????? ???????????????, ????????-??????????, ???????? ?????????, ? ????? ????????? ?????? ?????. ?????? ? ?????? ???????????? ? ?????????? ???? ???? ??? ???????? .

??????? ?????? COVID-19 ????? ????????? ? ????????????? . ????? ?????????? ? ???????? ?????????????? ??????, ??????????? ?????? ??????, ? ?????????? ???? ?????????? ?????????? ???????????????? ??????? ? ??????????? ?? ??????, ? ? ?????????? ????????? ???????? ? ????????? ?????????????? ????? ? ??????????? ??????? . ? ????? ???????????? ?????????? ??????????? ????? ?????????????????? ? ???????? ????????????????? ??????????? ? ?????????, ??? ????? ? ????????????????? ????????? , ??? ???? ?????? ???????????? ???????? ? ?????????? ?????????? ??????????? . ??????????????? ???????? ?????????? ??????? ??????????? ? ????????????, ??? ???? ?? ??????????? ??????? ??????????? ??????? ??????????? ????? , ?? ??????? ??????? ????????? ?????????? ?????????????? ????? . D-????? ?????????? ? ?????????? ??????????? ??????? ????????? , ? ?????????? ?????????? D-?????? ????? ????????? ?? ??????? ????????????????? ??????? ?????? ??????? ? ?? ????????????? ???????????? . ?????????? ?????? D-?????? , ??????????? ? ?? ??????????? ?????????? ??????? ???????????? ?????? ???????????? ??????? ???????? ? ????????? ? COVID-19 .

??????? ??????? ??????????????? ? ?????? ??????????? ? ?????? ?????? ? ????????? ?????????, ???????? ??????????? ?????? ?? 4-? ????, ??? ???????????? ???????? ?????????? ?????? ? ??????? ??????????? ?????. ????????????????? ??????????????? ????? ???????????? ????????? ??????????? ??????????? ? 8—20 ???? . ?????? ??????????? ??? ?????? ????? ????????????? ?? ???????? ??????? ??????????????? ?????? .

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?????????? ?????????? ??????? ?????? SARS-CoV-2 ?????????????? ????? ???—??? ?????? ????? ?????????, ????? ???? ?? ?????????? ???????? ?????????. ??????????? ???????? ????? ??????????? ?????????? ??????? IgA, IgM ? IgG, ?????????????? ? ?????? ????? ? ?????. ??? ???? ? ??????? ??????? ???????? ?? ????????? ? ??????? ??????????? ????? ??????? ????? ??????? IgA ? IgG. ? ??????? 3—5 ??????? ????? ???????? ?????? IgM ? IgA ????????? . ? ????? ???????????? ????? ?????????????? ??????? IgG ??????????? ?????????? ????? ? ????????? ????????? ?????? 6 ??????? ????? ??????????? . ???? ?????????? ?????????? ???? ?????????? . ????? ????? ????????? ??????????? ?????????? ?????????? ???????????? ??????, ??? ???????????? ????????? ???????? ???? T-?????? ? ???????? ????????????? ???????? . ????????? ??? ?????? ????????? ? ???????????? ????????????? ? ????? ???????????? ????????? ????? — ?? ???? ?? ??????, ?????? ??? ?? ???????? ??????? ??????????????? ?????? .

? ???????????? ? ???????? 12 541 ??????????? ?????????? ???????????????? ????????? ??????????? ?????? ???? ?????????? ? ??????? 6 ??????? ????? ???????????? ????????, ??? ???? ????? ????????????, ? ??????? ??????????? ???????? IgG ? ?????????? ?????, ?? ???? ???????????????? ????????, ? ?????????????? ????????????????? ???????? ???? ????? ???. ?????? ?? ???????????? ?????????? ?????? ? ???, ?????????????? ?? ?????? ??????????? ??????????? ??? ?? ??????????? ????????? . ? ??????? ?????????? ?????????? ????????? ??????????? . ???????? ???????????????? ?????? ?? ??????? 2021 ???? ?? ?????? ???????? ???? ? ?????? ???????? ?????????? ????????? ???????? ? 3 ??????? ?? 1000 ????? ????????????? ????????? .

???? SARS-CoV-2 ???????? ???????????? ?????? ??????????? ??????????, ??????????????, ??? ??????? ?????????? ?????? ? ????????????????? ??????? ??????????? ??????? ??????????? ?????????? ?????????? ????? ???????????? ????????, ????????? ?????????????? ????? ????????? ?????????????? ???????? . ? 40 %—60 % ?? ???????????? COVID-19 ??? ?????????????? ?????-?????????? CD4+ T-??????, ??????? ????? ???????????? ????????? ????????? ?? COVID-19 . ?????????????? ? ?????-?????????? ? SARS-CoV-2 ????????, ??????? ???????? ???????????? ????? SARS-CoV-2. ????????, ??? ??????? ?????-??????????? ?????????? ?????? ?? ??????? ??????????? ???????? ? ?? ?? ????????????? ?? ?????????. ???? ?????? ???? ?????? ??????????????? ??????????, ??? ????????????? ????? ?????? ?? ????????? ?????? ?? COVID-19 . ????????????? ??????? ?????????? ????????????????? ??????? ????? ????????? ?????????? ??????????? ????????? ?????? ????????????? ???? I, ?????????, ???????? ?? ???????? ?????????? ??????, ??????????? ?????? ????????? ???????????? I ???? ? ????????????????? ????????? ? ????????? , ??? ? ?????? ??????????? ???????? ? ???????? ? ????????? ????????? .

????? ???? ????????, ??? ???????? ????? 6 ??????? ????? ??????????????? ????????? ?????? ?? ?????????? ?????????? ???????? 80 % ??? ???????????? ??????? ? ??????????? ?????????? ????????? ????? ????????? ? ?????????. ?? ??? ??? ? ???????? 65 ??? ? ?????? ??? ?????? ??????????? ?? 47 %. ? ?????? ???????????? ?? ?????????? 9 ??????? ????? ??????? ? ????? ??? 9500 ??????? ?? ???????? 3500 ???????? ????????? ???????????? ? ?????, ? ?????????? ????? 40 % ?????????????? ???????????? ?????????????? ????????, ??????? ????? ???? ?????????? ?? ???? ?????? ???????????? .

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??? ????????, ?????????? ??????? SARS-CoV-2, ????????????? ?????? ?????????? 1—14 ???? , ????? ????????? ????????????, ? ?????? ????? ? ? ??????? ?????, ? ?????? ?????? , ?? ?????? ??????????? ??????? ???? ??? ?? ???? . ???????? ??????????? ? ??????? ?? 5—6 ???? ? ??????? ????????? . ???? ????????? ????????? ? ??????? ??????????? ?????????????? ???????, ?????? ??? ????? ????????? ??????????? ?????????? ?????????? ??????????? ??????, ? ????????? ?? ????????????? ????????????? ?????? ?? ????????? 10,6 ???? . ???????? ? ??????? ?????????? ?????? ?????????????? ? ??????? ?????? . ? ??????? ???????????? ????????? ?? ????????? 20 ???? .

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???????????????? ??????? ?? ?????????? ?????????? ???? ? ??????? ????????? ????????? (? ??????? ??????? ?? ???????????? ?? ?????????????)
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??????????????	7 (4—8)
??????	8 (5—13)
?????? ????????????? ????????-???????	9 (8—14)
???????????? ?????????? ??????	10,5 (7—14)
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?? ?????? ?????? ????????????, ? ???? ?????????, ??????????? ? ????????, ?????????????? ????????? ? ????????????? ?? ????????????? ?????? . ???????????? ???????, ?????????? ????? ???????????? ??????????, ???????? ???????????? ????????? ?? ???? « ???????? ?????? », ????????????? ? ???????? ?????? ?????? ?????? ? ???? ??????? ????? ??????? ??????? . ? ?????? ???????????? ?????????? ?? ????? ?? ??????? ?????????????? ? 75 % ??????? . ??? ???? ????????? ????? ?????????????? ? ? ????????????????? ??????? ???????? . ? ????? ????????? ??????????? ?????? ????????????? ????????-??????? . ??? ?????? ????????????? ????????-???????? ????? ?????????????? ????? ?????????? , ???????? ??? ?????? , ?????????????? ???????? .

????? ?? ???? ???????? ???????? ??????????? ??????????????? , ?????? ? ??????????? ( ???????????-??????????? ) ??? .

? ?????????? ????????? ???????? ??????????? ????? ???? ????? ? ?????????? ????????? ????????? ? ???????????? ??? ? ????????? ?????????, ???????????? ??-?? ????????????. ????? ???????? ????? ???????? ????????? , ?????? ? ????????? .

??????????? ?????????? ???? ???? ?????????, ?? ????????? ?? ????????? ? ????? ??????????? ?????? ????????? ? ????? ??????? ????? , ?????? ?? ??????? ????????????, ??????? ????????? . ?????????? ????? ????? ????? ??????????? ???? ? ? ????? ?????? ????? . ???????? ??????? 2143 ??????? ??????????? ????? ?????, ??????? ? ??????????? ?????? ??????????? ???? ? 5,9 % ???????, ? ????? ????????? ??? ???????? ???????? ????????? ???? . ????? ? ????? ????, ??? ? ????????, ????? ??????????? ????????????? ????????? ??????? ???????? . ???? ????????? ? ????????? ????? ? ?????????????? ?????????????? ????????? , ????????????????, ????????? ? COVID-19. ??????? ??????????? ????? ? ????????? ???????? ? ? ???????????-??????????? ????? .

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? ??????????? COVID-19 ????????? ? ?????? ??? ??????? ?????, ?? ? ????????? ??????? COVID-19 ???????? ??????? ?????????????? ????????, ?????????? ??????????? ??????? , ??????? ????? ???????? ? ??????????? ????????? ? ??????? ?????????????? ????????-????????. ??? ???? ??????? ???????????? ?????? ????? ??????????? ? ?????? ????????? . ?????? COVID-19 ?????????????? ????????? ????????????? ????????? , ??? ??????? ??????????? ?????????? ??????? ????????????-6 (IL-6), ?????????????? ? ??????????? ????????????????, ?????? ????????????? ????????-????????? ? ???????????? . ?????????? ?????? ????????????????? ????????? ????? ????? ????????????????? ? ???????? ?????????? (????.) ( .

?????????????? ???????? ????? ????????? ????????-?????????? ???????, ??????? ? ???????? ? ?????????? . ?????? ????????? ??????????????? ??????????? ? ???????? ????? ?????? ??? ?????????? ??????? ?????????. ???????? ????? ????????? ???????????? ??????????? ?? ????????? ???????? ????????-?????????? ???????. ? ?????? ????????? ? ????????-??????????? ????????????? ? ??????? ???????? ????? ????????????? ??????? ???????? ?? ????????? .

????????? ?????????? COVID-19 :

?????? ????????????? ????????-??????? , ?? 15 % ?? 33 %;
?????? ??????????? ??????????????? , 8 %;
?????? ????????? ??????????????? , ?? 7 % ?? 20 %;
????????? ????????, ?? 6 % ?? 10 %;
?????? ???????? ??????????????? , ?? 14 % ?? 53 %;
??????????? ??? , ?? 4 % ?? 8 %;
?????????????? , ? 33 % ???????????;
????????????????? ???????????????? ??????????? , ? 71 % ????????;
?????????? ????????????, ?? ???????????.

?????? ?????????? ???????? ?????????? ? ????????? . ????????? ??????????? ???? ???????? ? 0,215 % ??????????????????? ?????????, ?????? ????? ????????? ? ??????? ???????? ??????? ??? ??????? ????????????? ?? 6,7 % .

??????????????????? ???????, ????????? ? COVID-19

??? COVID-19 ???????????? ?????????? ?????? ????????? ?????????. ?????? ????? ??? ?????? ???? ? ??????? ??? ????, ??? ??? ????, ????????? ??????? ?????????. ??? ????????? ????? ? ? ?????? ?????????????????? ???????? IL-6, ??????????? ????? ?? ???????? ???????? ??????? ???????????? ??????. ??????? ????????? ??????? «??????????? ?????» ? ??? ??????? ???? ? ?????????? COVID-19 ???????????? ????????????? ?????????????????? ??????? ???????, ????? ??? ??????????????? ? ??????? ?????????? ? ?????????? IL-6, ??? ? ???????? ??????????? ?????????, ??? ? ??????????????? ??? ??????? ??????? ???? COVID-19. ?????????? ???? ??????? ?? ?????? ???? ?????????? ????????????? ???????????? ??????? « ??????? ????????????? ????????? » ?? ????????? ? ??????? « ??????????? ?????» . ?? ???? ??????? ? ??????? ??????? COVID-19 ??????????? ???????? ?????? ???????? ????????????? ?????????, ?????? ? ?????? COVID-19 ??????? IL-6, ????????? ????????? ??? ???????? ????????????? ?????????, ?? ??????? ????, ??? ? ??????? ??????? COVID-19 . ????? ???, ?????????? ????????? IL-6 ????? ??????? ?? ???? ?????? ????? ????????? ? ???? ????????? ?????? C-??????????? ????? ? ????????? ??????????? ????, ??? ???????? ???? ???????? ? ???????????? ????? ????????????? ???????????? ??????????? ???????? . ? ????? ????????????? ??????????? ?????????? ??? ????????????????? ????????? ???? ???????? ????????????? .

? ??????????? ??????? ???????????? ?????? ? ??????? ??????? COVID-19 ??????? ???????? ???????????????????? ????????, ?????????? ? COVID-19. ? ????? ?? ???????????? ??? ??????? ???????? ??? ????????? ???????? ???????????, ? ??? ????? ? ????????? ? ??????? ?????????? ???????????? ??????. ??????????? ????????? ??????????? ???????? ??????, ????????? ????????? ?????????? ?????????, ??????? ????? ?????? ???????, ???????????? ?? ??????? ???????????? ??????. ??? ???? ??????? ?????????? ?????? ? ?????? COVID-19 ???????? ?????????? ??????????, ????????? ?????? ?????????? ? IL-6 ???? ? ????????, ?? ?????? ?? ????????? ? ??????? ?????????? ???????????? ??????, ? ?????? ?????????? ? ?????? ??????? ? ?????? ???? ? ???????????????????? ? ??????????? ?????. ????? ?? ????????? ???????? ??? ??????? ???????????????? ???????????? ?????? ????? ????????? ? COVID-19 ???????? ????????? ?????????? ????????? ? ?????????????????? . ?????? ??-?? ??????? ?????? ????????? ?? ????????? ? ??????? ?????????? ???????????? ??????, ?? ??????? ???????? ????????? ????????????? ???????????, ????????? ?????????? ???? ?????????? ?? ?????? ????????? ???????????? ?????? ? ?????????????? ??????????????? ???????? ??? ?????????? ???????????? ?????? ????? ????????? ????????. ????????, ??????? ??????????? ?????? ????????? ?????? ????????????? ?????????? ?????????? ??????? .

? ???????? ?????????? ???????????? ?????? ?????????? ?????? ??????????? ????????? ?????? ????????????? I ????. ???????????? ???????? ??????????? ?????????? ?????? ????????????? I ????, ??? ????????????? ? ??????? ???????? ???????????. ?????? ??????????? ????????? ?? ???????? ?????????? ????????? ? ??????? ?????? 10 ???? ???????????. ? ?????????? ??????????? ???????? ???????? ???????? ? ??????????????? ? ???????????? ??????. ???????????? ????? ????????? ? COVID-19 ????????, ??? ??????? ??????? ????????????? ? ??????????? ??????? ????????????? I ???? ? ?????????? ?????????, ????????? ???????? ?? ??????? ???????????. ?????????? ?????? ?????, ????????????? ????????????, ???????????? ? ?????????? ??????? ????????? NF-?B ???????? ? ???????????? ?????? ? ???????????????, ?????????????? ? ?????????? ??????? ????????? .

????????????

??????? ?????????? ??????, ?? ????????? ?? ?????? ???????? 2020 ???? ???? ???????????? ?????? ? ??????? ????????-??????????, ???? ?? ??????? ??????????? ? ??????. ??? ??????? ???????? ??????????- ?????????? , ???? — ????-??????? . ?????? ????? ??????? ???????? ?????????? ??? ??????? ?????? ???????? ???? ???????????? ? ????????????? ? ???????????????? ??????????? ?????????? .

?????????????? ????????????

????????? ??????????? ??????????????? (???) ???? ????? ???????????? ?? ???????? ????? ????????? SARS-CoV-2 :

?????????? ??????????? ????? ????? ?????????

????????? ???? ???? ? ????? ??? ???????????????? ?????????;
??? ????? ??? ??????? ?????????? ??? ? ??? ???????? ?????? ??? ??????????? ????????? ? ??????????? ???????????? ?????? ???;
????????? ????????? ? 1 ???? ?? ????????? ? ?????? ????? ? ???????????? ??????, ????????, ???? ? ??? ??????????? ????????????? ???????? ??? ?????????? ???????????;
?? ??????????? ?? ??????? ?????? ???, ??? ? ?????;
??? ??????? ?????????, ????? ? ????????????? ??????? ?????????? ? ??????????? ?????????? ?? ???????.

???? ??? ????????????? ???????? ????? ????? ????? ?????????? ?????????????? ?? ????????? ????????????, ?? ???????????? ?????, ??? ?? ??????, ???????? ???????????????? ??????????, ?????? ??? ?????????? ?????? ? ???????? ???????? .

???????????? ???????? ?? ???????????? ??????????? ??????, ?? ???????????? ??????????? ??????? ??? ? ??????, ?????? ????????? ?????????????? ??????????? ?? ???????? ??????? ?????????. ???????????? ???????? ????????? ?? ? ??????? ???????? ??????????? ????????? ?????? ???????????? ???????????. ????? ???????????? ???????? ???????? ???????? ????? ???????? ??????? ?????????????? ????????-???????? . ??????? ????? ???????? ????? ?? ?????????????, ????????? ?????????? ???????? ?? ??? ???????? ????? ?? ????????? ?????? ? ??? ???????? ????? ???? .

???????????? ??? ??????????

??????????? ????? ???????? ????????? ????????????? ? ?????? ??????? ????????????? ????????? ??? ? ?????? ????? ?? ???????, ? ???????? ????? ???? COVID-19 . ???????????? ?????? ? ?????????????? ??????????? ??????????, ??? ??????? ????? ???????? ????? ????????????? ????????? ?????? ????? ? ???????????? ?????????? ????? ? ????????????. ??? ??????? ?????????, ?????? ? COVID-19, ??? ??????????? ??????? ??????? ????? ? ??????????? ?????????? ?? ?? ??????????? ????????????? ? ??????????, ????????????, ???????????????? ? ??????????? ?????????? ??? ?????? ????????????, ????? ??? ? ?????????? ????????? ?? ????????? ? ?????? ????? . ?????????? ????????????? ?????? ??????????? ??? ????????????? ????? .

??? ??????????? ???????????? ?????????????? ??? ???????? ????????? ????? ?????????? ? ??????????? ????????????? ????????? ?? ??????????? ??????? , ???????? ????????? ????????????? ????????? ?? ?? 08.04.2020 ???????????????? ???????? ??? ???????? SpO ₂ ????? 93 % .

???????????? ??? ????????

?????????? ? ??????????????? ????? ?????????? ????? ?? ????? ???????? ???????, ??? ??? ????? ?????????? ? ?????????????? ??????????????? ???????? SARS-CoV-2 ??? ??????? ?????????? ????? ?????????. ????? ????? ????????????? ???????? ??????? ??? ?????? ?????? ? ???????. ???????????? ????? ??????????, ??? ????? ???????? ??????????? ???????????? ??????? ???? . ???????????? ?? ?? ??????? ????? ? ?????? ??????? ????? ?????????? ???? ?? ????? , ?????? ?????? ??????????? ?????????? ???????? ????? ??? ?????? ??????? ??? ?????? ???? . ???????????? ??? ? ????? ?????? ???????? ? ??????? ????? ????????? ?????? ? ???????? ? ???????? ???????????????? ???????? ??? ??? ????????????? ??????????? ??????????? ???????????????. ? ???????? ????????? ??????????????? ???????? ? ?????????? ?????????? ????????????? ???????? ????? ? ???????????? ??????, ????????, ? ?????????, ?? ??????? ??????, ? ?????? ?????????? ???????? ??????????? ? ? ??????????? ????????? ????, ? ??? ????? ? ?????? . ????? ?????????? ?????? ????? ?????? 2—3 ???? ???????, ??????????? ????? ?? ????????????? ??? ?????????? ????????????? ??? ?????????, ???????????? ?? ?????????? ???????????? ????? ????????? ?????????????? .

??? ?? ??????????? ?????????? ?? ????????? ??????? ????????? ???????? ? ???????????? ?????? ??? ???? ???????? ??????????????? ???????? SARS-CoV-2, ??????????? ???????? ????? ??? . ??????? ????? ??????????????? ??? ??? ????? ?????????????? ??? ??? ??? ????????, ??? ? ? ??? ???????? ????????????? ???????????? ??? ????? ?? ???????? ??? ??? ?????? . ??? ???? ??????????, ??? ?????????? ?????????? ???????? ????? ????????? ? ????????? .

???????? ????????? ?????, ???????? ????????? ??? ?????????? ????? ? ???????? ?????? ? ??????? ???????? ? ???? , ? ????? ????????????? ?? ??????????? . ??? ???? ??????????? ?????????? ????????? ?? ??????? ???? ? 1 ???? ? ??????? ??????, ????????, ???? ? ??? ???? ???????? ?????????????? ??????????? . ? ?????? ?? ????????? ?? 17 ?????? 2020 ???? ???????????????? ??????? ???????? ???????? ?? 14 ????, ????? ?? ???????? ????? ?? ????????? ????? ????? ??? ????????????? ?????????? ????????????? ????????????, ???? ?? ????????? ????????, ?????? ? COVID-19 .

???????????? ??? ??????????? ??????????

??????????? ?????????? ??? ??????????? ???????????? ????? ??? ????? ?? ????????, ? ??????????? — ??? ?????????? ????????, ?? ????? ??????? ????? ????????? ?????????? ? ??????? ????????? . ??? ????????, ??? ??????????? ????? ?????? ???? ??????????????? ??? ??????????? ??????????, ? ????????? ??? ????? ??????? ?????? ???????? ???????????? ? ???????? ? ????????????? ??????? ?????? ????????????, ? ?? ????? ??? ??????????? ?????????? ????? ?????????? . ??? ?????????????? ??????????????? ???????????????? ???????? , ? ??? ????? ????? ???????????? ?????????, ?????, ????? ??????????? ????????? ????????? ???? ???????????????? .

??????? ???????? ? ????????????? ??? ???????? ? ???? :

?????????? ??????? ??? ? ????????????? ???????;
??????????? ???? ????????????????, ??????? ??????? ?????????? ?????, ???????????? ??????????? — ??????? ?????????????? ?????? , ???????? ?? ???????? ? ????????;
?????????????? ???? ????????????????, ??????? ?????????? ?????????? ?????????, ??????? ??????????? ?????, ???????? ? ?????????????? ??? ?????? ????, ??????????? ????????? ?????????, ?? ??????????? ????????? ?? ? ?????? ? ????????????? ????????? ;
?????????? ??? ???????????????? ??? ?????????? ????????, ??? ??????? ????? ????????? ?????????? ? ??????? ????????????????? ?????????;
????????? ?? ???? ???????????? ???????? ??? ? ???????????? ????????.

? ??????????? ??????????? ????? ????????????? ??????? ? ????????? ??????????? ??????, ???????, ????, ???????????? ??????? ? ?????? ????????????. ???????????? ?????? SARS-CoV-2 ???????? ???????? ????? (70—90 %), ?????????? ?? ????? ???????? (????????, ?????????? ), ???????? ???????? (????? 0,5 %) .

????????????? ??????? ???????????? ??????

?? ?????? ?? ???? 2020 ???? ?????? ?????????? ?????, ??????? ?????? ? ?????????? ????????? ????? ??????, ?????????????? ? Lancet , ?????????? (??????? ???????? ?????????????) ???????, ??? ??????????? ??????? ??????????? ????????? ?????????? ????????? ????? ?????? ? 1 ???? ? ?????, ????? ???????, ??????????????? ????????? ??????????????? ????????. ? ??????? ??????? ??????? ????????????? (?????? ???????? ?????????????) ??????? ??????????? ?????????? ??????? ????? ? ?????? ????. ???????????, ??????????? ??????????, ??????????? ????????? ????????? ? ??????? ?????? ?????? ?????? ?????, ? ? ?????? ??????, ??? ????????? ???????? ??????????, ?????????? ???????????? ????? ??? ???? ??? ??????????? ? ?????? ???? (??????? ????? ??? ????) . ??? ???? ????????????, ? ???? ???????? ????????????????? ??????????????? ?????? ?? ???????? ????????, ????????, ??? ??????? ????? ???? ?? ???? ?? ????? ???????? ?????, ??? ??? ????? ? ????????? ????????? ????? ???????? ???????????????? ? ?????? ???????????? ?????? ????? .

???? ???????????? ????????????

?? ????? ???????? ???????? ??????????? ????? ?????????????? ??????????????? ???????? ???????? ??????????????? ?? ?????????? , ??????? ?????? ???????????, ????????????? ?????????? ? ??????? ?????????, ???????? ???????, ? ????? ????????????? ?????????? ????????? ?? ?????????? ? ??????????? ??????? . ?????? ?????? ????????? ???? ??????????? ??????????????? , ??????? ??????????? ??????????? ????? ????????, ???????? ???? ? ?????????????, ??????? ?? ????????? ?????? ? ????????? ?????????? ? ???????? . ???????? ???? ????? ?????? ????????? ???????? ??????????????? ???????? . ????? ????????? ? ???????? ??? ????????????? . ???????? ???????????? ????????????? ?? ????? ???????? COVID-19 ???????? ?????? ?????? ???? ? ?????????? ??????????????? ???????? ? ???????? ??????????, ?? ??????? ?????? ??????????? ????????? ????????? ?????? ? ??????? ?????? ???????????? ??? ???????? .

? ???? ????, ??? ???????? ???????????? ????? ???????????????? ? ?????? ?????? ? ??????? ? ?????????? ?????? ???????, ? ????? ??????? ????? ????? ????? ???????? ??? ?? ???????? ??????????????? ???????? .

??????????????????? COVID-19

?????????? ?????? COVID-19 ????????????? ??? ???????????? ?????????????? ?????????? ?????? ?????? SARS-CoV-2 ????? ?????????? ??????????? ???????? ???????. ??-?? ?????????? ???????? ??????? ??????????? ?????????? ?????????? ? ??????????? ???????, ??????? ??????? ???????? ?????, ??? ???????? ????? ??? ??????????? ?????????? ? ?????, ???????? ? ?????? ????? . ?? ???? ???? ???????????? ?????? ????????? ??? ??????? ????????? ?? ?????? ?????? ???????????????, ?? ????? ??? ???????????? ? ???????????? ?????????, ???????????? ?? ???????????????? ?????????? ?????? ??? ??????????? ?????????. ?????????? ?????????? ??????-?????????? ? ?????? ???????????? ???????? ? ???????????? ??????????? ????? ???????? ? ???????????????? ?????????? ????????????, ? ???? ??????? ????? ????????? ?????? ?????????? ? ??????????? ?????????? ??????? ??????????? ??? ?????? ???????? ??????? . ? ????? ???????? ?????? ???????????????? ?????? ??????????? ?????? ???????? ??????????? ? ????????????, ????????????? ?????????? ? ??? ????? (????? ??????). ?????? ?????????????? ???????????? ?????????? ??? ?????? ?????? ? ???????????? ??????????? ? ??? ????????? ??????? ????? ?????????? ??? ??????? ? ????????? .

?? ?????? ????????? ??????????? ??????????????? ?? ????????? ?? 17 ??????? 2020 ???? ? ????????????? ?????????? ???? 166 ??????-??????????, 56 ??????-?????????? ????????? ??????????? ????????? . ?? ????? ????????????? ?????? ? ?????? ???????????????? ???-?????-??? (??????? V), ???????????? ? ??????? .

?? ?????????? ?????? ?????? ??????? ?? ????? ??????? ???????????, ?? ????????? ??????? ????????? ???????? ???????, ????? ????????? ????? ???????? ??? ?????????, ??? ???????? ?????????? ???????? ????????? ? ??????????????? ? ????????????? ???????? ??????? . ?????? ?? ???????? ? ?????? ???????????????? ?????? ?????? ??????????? ? ??????? ???? ?????? ????? ?????? ??????????, ? ?????? ???????????????? — ? ??????? ?????????? ?????? , ??? ????????, ??? ? ???? ?????? ???????? ??? ??? ?????? ??? ???????? SARS-CoV-2 . ??????? ????? ????? ????????? ???????? ????? ??? ????????????? COVID-19, ????????? ?????????? ????????, ? ??????????? ????????????? ? ?????? ???????? ??????? .

??????????, ???? ? ?? ????????? ????????? ???? ????????, ??????? ???? ???? ?? ????????? ? ??????????? ???????? ?????????. ?????? ? ??????? ??????? ??? ???????? ?? ????? ???????? ???????? ???????????, ?????????????? ? ??????, ??????? ?????? ????????? ????? ???????? ??? ????????. ?????????? ????? ????????? ??????????? ????????? ?????? ????? ?? ???????????????? ???????? .

?????????????? ??????? ? ????????????

??????????? ????? ??????????? ?????????? ????????????????????? ?????? ??? ?????????????? ????????????? COVID-19 ????????????? ???????? .

???????? ????????????? ?? ???????? ? ????? ??????? ??? ???????? ??????????????????? ??????????, ?????? ???? ??? ?? ???????, ? ?? ?????????????? ??????????. ? ?????????? ????????????? ????????? ?????? ?? COVID-19 ??? ?? ??????????? ?????????? ??????? ??? ??? ?????????????? COVID-19, ???????????? ? ?????????? ???????? ???? ??? ???????????? ??????????? ????? ????????????? ? ??????? ? ?????????? ?????? ?????????????? . ?????????? ????????????, ??????????? ???????? ??????? ??????? COVID-19 ? ??????????? ????????? MMR , ??? ???? ???????????? ????????? ?? ????????? ??????? ????? ? 80 ???????, ? ??? ?????? ??????? ??????????? ???????? . ? ????? ???? ??? ?????????????, ??? ??????? ?????? ?????-???? ?????? ???????? ????? ???????? ?? COVID-19 .

???????????

????????? ??????????? ??????????????? ???????????? ???????????? ?? ???????????????? ??????????? ? ????? ? ??????????? ?? ???????? SARS-CoV-2 .

? ?????? ????? SARS-CoV-2 ???????????? ??????????????? ???????? ?????????? ?????????, ??????????????? ????????????? ??????????????? ?? , ????? ? ?????? ??? ??????????? ???????? ??? ???????????? ??????????? ???????????? .

???????????? ???????????

???????????? ?????? ???????

??????????????? ????? ???????? ??? ?????? ???????????? ?????? ??????? ? ???????? ????????????? ? ???????? ??????? . ? ?????? ?????????? ?? ????????, ?? ?????????????? ?????????? ?????, ????? ???? ??????????? ????????? ?????? ???????? ??? ??????? ?? ?????? ???????? ??????????? ????? . ? ????? ???????????? ? ???????? ? 5700 ????????? ? 3,2 % ??????? ????????????? ??? ????????? ??????? ????????????, ????????? ??????? — ????????????? .

?????????????? ?????

? ??????? ?? ???, ????? ?? ???????? ?? ?????????? ??????? ????????? ?????? ? ?????????, ?? ?????????? ??????? ?????????? ? ????, ?? ???? ??????? IgM - ? IgG -??????? ? ????? . ???? ?????????????? ???????????? ???????? IgG ? IgM, ?? ??? ????????, ??? ???????? ???? ? ??????? ?????????? ?????????????? ??????, ???? ?? ?????????????? ???? IgG, ?? ???????? ???? ?????. ??? ???? ????? ?? ??????????, ?????????? ?? ??????? . ????? ???????, ????? ????? ?????????????? ??? ??????????? ???, ??? ??? ??????????? .

?????????????????? ????????????

??? ?????????? ?? ????????? ????????????? ?????? ????? ???????? ??????????? ? ????? ??????, ???? — ???? ? ?????. ???? ???? ???????? ?????????, ?? ????????????? ?????? ?????? ?? ???????, ????? ?????? ??????? ????? ???? ???????? ? ??????? ???????????? ?????????? . ???????? ????????? ????????????? ????????? ?? ?? 26.10.2020 ??????? ???????????? ???????? ??? ?????????, ??????? ? ?????? ??????? ??????? ?????? ????????????? ????????, ? ? ?????? ??????? ??????????? — ?? ?????????? ?????????, ????????, ??? ??????? ???????? ????? . ?????????? ?????????? ?????????? (?? ??????? — ?????? ?????) ? ??????????? ? ??????? «?????? ???????» ???????? ??????????? ?????????? ?????????? ?????? .

? ????? ??????? ????? ?? ???????? ? ????????, ?????? ???????? ????????? ?????? ????????? ? ?????? ?????, ??????? ?????????? ?? ????? ????? ???? ?? ???????? ?? ????????????? ???????, ? ??????? ????? ????????? ???????? .

??????????????? ?????????? ? ??????????

????????? COVID-19 ??????????? ? ??????? ??????? ??????????? ???? ? ??????? ????????? ???????, ????? ?? ????? ??????????? ???????? ????? ????????????? ??????????? ?????????, ? ??????? ??????????? ? ??????? ???????????? ????? ??????????????? ? ??????? ?????. ??? ???? ????? ????????? ??????????? ??????????????? ??????????? . ??????? ??????????? ?????????? ??? ?????????????? ???????? ??????? ????????? (SaO ₂ ) ???? 90 %, ????????????? ????????? ???????? ? ?????????????? ????? ?????? ? ???????? ?????????? . ? ??????????? ?? ??????? ??????? ??????????? ?????????? ??????????????? ???????? ?????? ????? ??? ??????? ???????? ? ?????????????? ???????????? ?? ????????? ??? ????????? . ??????????? ?????????????? ????? ? ?????????? ??????? ?-??????????? ????? ??? ?????????????? ???? ????????????? ? ??????? ???????? COVID-19 ? ????????? ? ????????? ??????????? ??????? .

? ????? ?? ????????? ???????????? ????????, ??? ? ??????????? ??????? ??????? (????.) ( ? ????? ??? ? ?????, ?????? ?? ??? ?????????? ? 3-? ?? 4 ???????, ? ??????? ???? ?????????? ????????? ????????????? ???????? . ???????? ??????????? ?? 23 ???????? 2020 ???? ???????? ? 3 ?? 4 ?????? ??? ?????????? ??????? ????????? ?????????????? ?? ???????, ?????? ?????????? ?????? ??????????????? ??????? ? ?????????? ?????? ??????????, ?????????????? ????? ????????? ?? ???? ??????????? ?????????? ???????. ??? ???? ??????? ??????????????? ?????? ? ????? ??? ????????? ????????????. ? ??????? ???????????? ?? ??????? COVID-19 ???? ?? ?????????? ????????? ?? ?????????? ???????????? ???????? ?????? ???????????????, ??? ??????????? ??????????? ????????? ????????? ????????????? ???????? ?? ?????? ??????????????? ????????? ?????????????? ???????????? . ????????????? ?? ???? ?? ?????????????? ????? ????????? ?? ????????? ?????????? ????????????? ????????? ???????? .

??????????? ????? ????? ??????????? ????? ?????????, ?? ?? ??????? ?? ??????? ??????? ???????. ??????????? ????? ??????? ???????? COVID-19 ? ??????? ? ??????????? ?? ???????? SARS-CoV-2, ???? ???????????? ??????????????? ???????? ? ???????? ? ????????????? ????????????? .

? ?????????? ??????? ????????? ??????????? ?????????? ?????????? ???????? ?????????????? ????????? ? ?????? ????? . ? ????????? ???????????? ????????, ??? ? ?????????, ?????????? ? ????????? ??????????? ???????, ? ????? ???? ?????? IL-2 , IL-7 , IL-10 , (????.) ( , (????.) ( , MCP1, MIP1A ? ??????? ??????? ??????? (???-?) .

(????.) ( (??. ????????????? ??????? ) ????? ????????? COVID-19 ???????? ???????? ?????? ? ??????????? ???????? ? 83 % ??????? . ? ??????? ? ????????? ??????? ?????????? ??????????? ????? ??????? ?? ????????, ?????? ?? ?????? . ?????? ??????????, ? ??????? ???????? ??????????? ????? ????? ???? ??????? ??????????? , ?????????? ??????? ?????????????????????? ? ???????????????????????? ? ????????? ?????, ?????????? ??????? ??????????????????? , ??????? ??????? C-??????????? ????? ? ??????? ??????? ?????????? .

??????? ??????? ??????????? ??? ?????????? ??????? ???????????? ?????? ?? ??????? ????????? ???????????? ????? ?????????? ? ??????? ??????? . ?? ??????? ??????? ??????????? ????? ????? ????????? ??????????? ??? ?????? ? ????? ???????? . ?? ?????? ????? ????????? ??????? ??????? ? ????? ?? 2 ?????/? . ? ?????????? ???????? ????????????? ?????????? ??????? D-?????? ? ?????????? .

???????????????? ???????

?? ????????? COVID-19 ?????????? ???????? ?? ?????? ?????? ????????????? ????????, ? ?????????, ?? ???????? ? ?????? ???? . ????????? ??? COVID-19 ????? ?? ????? ???? ?????????? ????????? ?? ?????????, ????????? ??????? ?????????? . ???????? ???????? ??????????? ???????? ??????? ??????????? ??? ????????? ???????? . ? ??????? ?????????? ??????????? ??????????, ???????? ? ??????????????, ????? ???? ??????????? ????????????? ??? ?????????????? ???????? .

?????? ???????? ????? ???? ????????? ??????? ?? ?????????? ????????????: ????????????? ????????? ????? ???? ????????? ????????????? ??????? ????? ??? ??????? ???? ???????????? ?????????????, ?????? ???????? ???????? — ????? ???????????? ?????? ??????? ? ???????? ???????????? . ??????????????? ????? ????? ?????? ????? ????????-?????, ?????? ?? ????????????? ????????? ?? ????????? ????? . ????????????? ?? ??????? ?? ?????? ??????? ?? ????????? ?????????????? ????????? ??????? SARS-CoV-2 ( ?????????? ) . ? ???????????? ? ???????? 5700 ??????? ?????????? SARS-CoV-2 ? ?????? ????????????? ??????? ?????????????? ? 2,1 % ??????? .

???????

??????? ????????? ??????? ?????????????? ??????

?????????????? ????????? ??? ??????????? ????????????

??????????? ?????? ??????? ?????????? ? ?? ??????????? ? ???????. ?????? ??? ????? ???? ????????? ? ?????? ??????????? ????????????? ????????? ???????? . ? ???????? ???????? ???????? ???????????????? ? ?????????????? ??????? . ???????? ??????? ??????? ??????? ? ?????? ??????????? ???????????????? ???????? ??????????? ???????????? ?????? ??????????? ?????????, ????????? ?????????? ????????? ????? ???????? ? ??????????? ?????????? ? ?????? ???????? ?????? ??????? ? ?????????? ?????? . ? ??????? ??????? ??????? ?????????? ?? ??????????? ???????? ?????? ??????? ?????????.

???? ??????? ? ?????????? ?? ?????-???? ???????? ??????????, ? ?????? ??????? ??? ????????? ????????? ? ??? ?????????? ??????????? ???????? ???????? ???? ?? ??????? ? ???????? ????????. ?????? ??? ??????? ?????? , ????????????? , ??????????? ????????? ???????, ????????? ?????????????? ??? ?????????? ???????????? ????????? ???????? ?????????????? .

??? ????? ?????????????, ??? ???????, ?????????? ???????? ???????, ? ??? ????? ?? ?????? ????, ? ???????????, ??????? ???????????, ????? ?? ??????? ???????? ? ?????????, ?? ????? ??????? ???? ???????? .

?? ????????? ?? ???? 2022 ???? ?????????? ?????????????? ??????? (???????? " ^H ") ??? ??????? ??????? ????????????? ?? ?????????????? ??????? ?? ????????? ??????? :

?????????? ??????????: ????????? ??????????????? (+/- ?????????? ??-6), ^H
???? ???: (+/- ????????? ??????????????? ) ^H
???? ??????????????: ???????????? , ???????????? / ?????????
????????????????? ??????????????: ? ??????? D ( ????? ?????? ?????????????? ?????????????), ? ????? ????????? ??????????????? +
???? ???????????? ?????????????: ????????????
???? ???: ????????? ????-?????.

????? ??????? ?????????????? ??????? ???????? ? ????????? ????????????? ?? ??? ??? ???? ???????? ????????? ?????????? (????? ??????????): ???????? ?? ???????? ????????? , ??????????? , ??????? , ??????????? , ??????? ????????, ??????????? , ?????????????? ? ??????????????? ????? (????????, ????????? ???? ???????? , ?? ??? ???? ????? ???????? ???? ???????????? ), ?????????? ? (??? ???? ??? ?????? ??????? ????? ?????????? ???? ? ???? ??????????? ??????? ????????????).

?????????????? ???????

????????? ?? ???????? ??????? ??????? ??????????? ? ? ???????? ???????? ????????? ?????????????? ??????? ? ??????????? ??????? . ????????? ??????????? ??????????????? ??????????? ???? ??????? ?????????? ??????????? ????????? ??? ????????? ?????? ????????? ? ????? ? ??????????? ????????? ??????????? ??????? . ?????? ????????????? ????????-??????? ???????????? ???????????? ?????????? ??????. ? ????? ??????? ??????? ??????????? ?????????????????? ?????????? ??????????? , ??????? ???????? ??????? ? ??????????? ??????? ????????? ????????? ??? ?????? ????????????? ??????????? ??????????????? . ???? ????? ??????????? ? ??? ??????? ?????? ????????? ??????????????? , ??????? ????? ????? ?????????? ?? ???? ???????? SARS-CoV-2 . ????????, ???????? ????? ???????????? ?????????, ??????? ?????????????? ????????-???????? ??? ?????????????????? ?????????? ???????????, ?????? ???????? ?????????? ???? ???????????? ? ????? ???????? ?????? ??????? ? ?????????? .

????????? ??????????? ??????????????? ???????????? ??????????? ?? ??????? ????????????? ? ?????? ?????????? ?? ????? ??????????? . ? ???????????? ?????????????? ????? ???? ???????????? ??????????? ???????????? ???????? ????????????? ???? ? ???????????? ? ?????????????? ???. ???????? ???????? ? ???? ?????????? ?? ?????????? ?????????? ? ?????????? ?????????????, ?? ???????????? ?????????? ?????? ? ?? ??????, ?? ??????? ????????, ?? ?????????????????? ??????? ? ?? ??????? ? ?????????? ?????????? .

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??? ?????????????????? ?????????? ??????????? (????) ???????? ????? ???????????????? ? ??????????? ??????? ? ??????????, ?? ???? ??????????????? ????? ????????????? ?????? . ????? ?????????? ?????????? ? ?? ??? ????????? ?????????? ???, ? ????? ??? ????? ???????????? ? ?????? ???? ??? ??????? . ?? ??????? ?????? ?????? ????? ???????? ??????? ??????????? ????? ????????? ? ?????? ????????????? ????????-????????? .

?????? ??? ?? ???? ????? ???????? ???????????? ? ????????????? ???????? ??????????? ?????, ? ? ????? ?????????? ???????? ?????????? ???????? . ???? ?? ????? ?????? ??? ??????????? ??? ????????? ??????????????? , ?? ?? ??????? ? ?????? ?????????????? ?????? ??????? ??? ???????????? ???? . ????????? ?? ??????? ?????? ?????????? ??????????? ?????? ?????? ??????, ?????? ??????? ????????? ?????? ? ????? ?? ?????????? ???? ??? COVID-19 . ???????? ?????????? ???????????? ??????????? ??????????????????? ???????????????? ????? ????????? ? COVID-19 ?? 90-? ???? ? ?????? ??????? ???????????????? ?????????? ????????? 38 %. ? ???????? ??????? ????????????????? ???????????? ?????????? ???? ??? ?????? ??????????? ?????? ?????????? ?? 60-? ???? ?????????? 35 % ?????? 46 % ? ??????????? ??????. ??????????????? ?????? ????????? ?? ????????????? ?????? ?????????? ???? ? ??????? COVID-19 .

? ???????? ???????? ?????????? ???? ??????????, ??? ? ? ?????? ???????? . ? ??????? ? ?????? ????????? ? ????? ??????? ?????? ?????? ????? ???? ??????? ??????????? ????????? ??? ????????? ?????? ????????? ? ????? ? ???????? ?????????? .

??????? ?????????????????

SARS-CoV, MERS-CoV ? SARS-CoV-2 ???????? ? ???????? ??????? ????????? , ??????? ??????? ???????? ????? . ???????? ????? ???????? ????? ?? ?????? ????????????? ??????? ??????????? ?????? ? ??????? ?????????????? ????????-???????? . ? ?????? ???????? ?????? ??????????? ???????????????, ?????? ??? ?? ????????????? ?? ????????????? ??? ??? ??-?? ?????????? ????????????? ????????? ????????????? , ????????? ?? ??????? ??????? ????????????, ?????????, ??? ????? ???? ???????? ??????? ?????????? . ???????? ??????????????? ??????????? ???????????? RECOVERY , ???????????? ? ??????????????, ???????????? ???????? ?? ????? ??????? ?????????? ?????????, ??????????? ?? ????????????? ?????????? ??????, ? ?? ????? ????? — ????? ?????????, ??????? ????????? ??????????? ??????? . ?????????? ? ??????????????? ????? ??????? COVID-19 ?????????? ??????????? ??????????, ??? ????????????????????, ????????, ??? ?? ??????? ?????????? ? ???? ????????????? ???????????? ?????????? ?????? ????? ????????? ? ????????? ? ??????? ?????? ?? ??????? . ?????? 1707 ????????? ? ???????????? ?? ??????? ??? ????????????, ? ?????? ? ???????? ?????? ???????????, ??????? ???? ????????? ???????????????? ?? ????? ????????? ? ?????????????? ????????????? .

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???? ?? ???????? ??????????? ????????????????? ????????? ? ????????????????? ???????, ????????, ? ??????????? ??????????????? ???????, ???????? ??????? ?????? ????????? ? ?????? ???????? ???????????? ??????????? ???????????? . ???????????? ????? ??????? ????? ???? ???????????, ??? ????? ??????? ?????? ???????? ???????????? ? ????????????? ????????????????? ??????? . ?????????? ?????? ???????? ?????????? ???????, ???????????? ??? ???????? ??????????????, ??? ? ???????? . ??? ??????????? ???????? ??? ?????????? ????????????????? ?????????????? ???????????? . ?????????? ???????????? ?????? ???? ???????????????????, ?????? ???????? ???????????? ???????? ? ?????? ????? ???????? ? ?? ??????????? ?? ???????? ??????? . ?????????? ?? ??????? ? ???????????? ?????????????? ????? ??????? ???? ?????????, ??????????? ? ??????????? ????????? . ????????, ???????? , ???????????????? , ??????????? , ? ????? ????????? ? ????????? ????????????? ? ????????????? ?????????? ????? ?????? ??-?? ??????? ? ??????? .

?????????? ??????? ?????? ???????????? ?? ?? ?????????, ? ?? ??????????? ?????????????, ?????????????? ?????????????. ???????? ?? ????? ???????? ?????????? ??? ?????????? ??????????????? ???????????? ????????? . ??? ??????? ???????? ?????????? ?????????????? ?????????? ????????????????? ??????? ??? ??????????? ???????????? ? ????? ? ?????????? ?????????, ???? ??????? ??? ??????????????? ? ??? ???? ????????. ???????? ??????? ?????? ????????? ??? ???????????, ? ?????????? ?????? ???? ????????????????? ? ????????????? ???????? ? ???????????? ?????????? .

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? ??????????? The LIVING Project ???????? ????? ???????????? ??????? ?? ????????? ?????????, ? ????? ??????? ???????? ?????????? ?? ???? ?????? ?? 20 %, ???????? ????? ????????? ?????????? ?? 20 % ? ???????? ????? ???????????? ?????????? ?????? ?? 20 %. ???????? ??????????? ???? ?????????????? ??????????????? ????????????????? ? ?????????? ?????????? ? ?????????? ? ???????? ?????????? ?? ???? ?????? ? ???????? ????? ????????? ??????????. ?????????? ?????????? ? ?????????? ????? ???????????? ?? ????? ???????? ????? ????????????? ???????????? ?????????? ??????. ??? ????????????? ????????????? ??? ??????????????? ?? ????????? ?? ??????????? ?????? ??? ????????? ???????: ?????????? ?-1a ? ???????? .

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?? ????? ??????????? ????? ??????????? ???????? (?????????????? ????????) ?? ? ???????????, ?? ? ????????? ? ???????????? ??? ?????????????, ??? ???? ??????????? ???????? ???? ???????? ???????? .

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?? ????? ??????? ??????? ? ????????? ??????? ???????? ????????? ? ????????????????? , ??? ????????? ???????????? ?????? ??????????? ??????????, ?????? ???????? ?????????? ????????? ????????? ? ????? 10 % ???????, ????? ??????? (????.) ( , ???????????? , ???????????????????? ???????? ??????? ? ??????????? . ?????? ?????????? ??????? ????? ??????????? ???????? ?????????????? ??????????, ? ????? ???? ?? ????????????? ???????? ????????? ???????? ?????? , ???????????? ?? ?????????? ? ??????????????? ????? ???????????? ?????????? ????????????????? ???????, ??? ?? ?? ??????? ?????????? ????? ??????????????????? ?????????. ?????? ? ?????????? ? ????????????? ??, ????????, ??????????? ?????????? . ?????????? ?????????????? ? ??????? COVID-19 ???????????????, ???? ?????? ?? ???????? ????? ?????????????????? ???????????? ? ????? ???????????? . ????????? ???????????? ????????? ? ?????????????? ???????????, ??????????? ????????????????, ?? ?????????? ??????-???? ????????????????? ??????? . ??????????? ?????????? ???????? ????????????????? ???????????? ???????????? ????? ?????????? ?????????, ??? ???? ? ?????? ????????????????? ???? ??????????? ???????? ??????? .

???????????

?? ??????????? ???? ???????????? ? ???????? 8822 ????????? ???? ????????, ??? ??????????? ?? ?????? ?? ??????????, ???? ? ????????????????? ??? ? ????????????????? ??????????????. ??????? ??????? ????????????? COVID-19 ?? ????????? ??-?? ????????????? ????????????? ? ???????? ????? ???????????? ????????????????????????? .

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???????? ??????? ?????????? ????????, ??????? ???????? ? ?????? ? ???????. ????????????????? ?????? ???????? ???????? ? ????? ?????????????? ? ????? ????????? ??????????? ?????? ????? ????? ???????????, ??????? ???????? ???? ????????????? ???????? ???????? ? ??????? ????????? ???????? ??????????? . ????????????? ????-?????? ?? ????????????????? ?????? ?????????? ?? ????????? ?????? ???, ??????????? ????????????? ? ???????????? ?????? ????????????????, ??? ? ??????? ???????? ????????????? ????????????????? ?????? ?? ?????? ??? ??????????? ?? ?????? ?? ?? ?????????? ? ??????? 28 ????, ?? ?? ??????????? ????????? ??????? COVID-19 ??????? ??? ??????? ??????? ??????? .

?????? ?? ???????? ? ???????????? ??????????? ??? ??????????? ?? ???????????? ????????????????? ?????? ? ??????? ??????? ???????, ?????? ? ???????? ??????? ????????????? ?? ???????????? ? ??????????????????? ??????? ??? ????????? ? ?????? ???????? ??????? (?? ??????????? ?????????? ? ?????? ??????????? ????????? ????? ?????????, ??????? ?? ????????? ???????????? ?????????? ??????). ??? ?????-???? ???????????? ?? ??? ?????? ?????????? ????? ????????????????????? ????????? ??? ????? ??????? ? ??????????? ?????? ???????? ??????? ???? ???????????? ?????? .

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?????? ? ?????????? ????????????? ??????????? ????????? ?????????????? ??????????, ?????????? ???????? ???????????? ??????? . ??????? ??????????? ????????????? ???????? ??? . ???????? ?????????? ?????????????? ???????? ? ??????? ?????? ???????? ? ?????????????? ????????? ???????? ??????? 5 ?????? ??? ??????, ? ? ??????? 10-?? — 12 ?????? ? ?????? . ?????? ???????????? ??????? ???????????? ??? ???????? ????????????? ????? 2 ??????? . ???????? ????? ???????? ? ???? :

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??????????????? ?????????????? ???????, ????????? ? COVID-19

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????? ???????????? ??????? ????? COVID-19 ????????? ????? ????????????? ???????????? ?? ????. ???????????????? ??????????? ????? ???????? ? ???? ?????? ??????????? ??????, ?????????? ???????????? ????????, ???????????? ?????????? ??????????, ?????????????? ???????, ????????? ? ??????? ??? ? ??????? ????, ??????????? ??????????, ????????? ? ??????? ??? ????????? ? ??????? ???????, ????????? ?? ????????. ???? ??? ??????? ????? ????????? ?????????????? ???????????? ?? ????????????, ? ?????? ????? ??????????? ?????? ??? ???????? .

??? ????????? ?????????? ?? ????? ???????????? ????? ????????????? ????????? ? ?????. ???????? ???, ????????? ? ????? ????????? ???? :

?????? ?? ?????????, ???????? ?? ????????????? ??????? ???????? ??????? ? ????????? ?????;
??????? ?????? ????????? ??? ?????????? ??????????? ?????????? ?????????? ???? ? ??????????, ?????????????? ?????????? ??????;
??? ???????? ????????? ?????????? ????????? ? ???????? ?????????, ? ?????????? ???? ???????????? ???????????? ???????????? ??? ?? ?????????? ????????? ? ????????? ????????????;
????????? ???????? ???????, ??????????????, ??????? ??????, ???????? ?????? ????, ??????????? ?????????????, ???????? ??????????? ? ????? ??? ???? ??????????? ????.

???????

??????????? ?? ??????? ?? ????????? ?? 1 ?????? 2020 ?.
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???????	8,7 %
??????????????	7,1 %
????	6,5 %
?????	2,3 %
???	1,7 %
????????	1 %
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? ?????? ????? ????????? ???????? ??????????? ?? 72 314 ??????? ? 31 ??????? 2019 ?? 11 ??????? 2020 ????.

??????????? ? ??????? ??????????? ??????? ? ????????? ????????? ? ???????? ????????????? ??????????? . ???????? ???????? ????????? ??????? ???????? ??????????? ??????????????? , ????????????? ?? ???? ??????? ?????????????? ????????-???????? . ????? ????????????? ????? ?????????????? ??? ? ?????? ???????? ??????????????? .

???????? ??????? 44 672 ?????????????? ??????? ? ????? (?? ?????? ????? ? 72 314 ??????? ?? ?????? ? 31 ??????? 2019 ???? ?? 11 ??????? 2020 ????), ??????????? ?????????? 2,3 %. ????? ???????? ???? ?????? ??????? ????? ????????? ?? 60 ??? ? ????? ? ???????????? ?????????. ????? ?????????? ??????? ??????????? ?????????? 49 % . ???????? ??????????? ????? ????????? ??? ????????????? ??????????? ? ????? ???? ??????? ???? ? ?????????? 0,9 % .

??????? ??????????? ????? ?????????? ????? ????????, ? ????????? ??????? ??????? ??????????? ???????? ????, ??? ? ?????. ? ????? ?? ???? ?? ????????? ?? 8 ?????? ?? ?????????? ???????? ? 5,85 % . ??????????? ????? ??????????????????? ??????????? ?? 4 % ?? 11 % . ?? ???????? ????? ???????? ????? ?????? ????????? ??????? . ????????, ??????? ??????????? ? ?????? ? ?????? ???????? ???????? ??????????? ??????? ??????????? ???????? ????????? ? ?????? .

? ????????? ? ??????? ?????? ????????????? ????????? ? ??????????????? ????????????? ????????? ??????????? ? COVID-19 ??????? ????. ?????? ??????????? COVID-19 ????? ???????????????? ? ??? ?????? ??????? ?????? ?????? .

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? ????? ????????, ?????????????? ??????? ??????????? ?????????? ??????? ? ??????? ?????, ??????:

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?????, ???? ?? ?????, ?? ???????? ???????? ????? ??? COVID-19 , ?? ?????? ?? ??????? ?? ???????? ? ???????????? ??????????? ??? ????????? ????? ????? ????????? ????? ??????? ??????? ? ??????? ????? .

???????????? ???????? ???????? ????? ? ?????? ???????? ??????? ??????????? — ???? ????????? ??????????? ???????, ??? ?????????? ?? ???????? ??????? ??????????? ???????? ?????, ??? ? ????????????. ??? ???? ????? ?????????, ??? ?????????? ??????? ? ????????????? ???????? ????? ? ??????? ???????????? ????????? ? ?????????????????? ?????? ??? ??????????? ?? COVID-19 .

???????? ???????????????? ?????? ?????????-???????? ?????????? ??????? ????????? ?????????????? ???????? ???? ???????? ???????? ??? ???????????? ?????????, ? ????? ??????? ?????????????? ????????-???????? .

?? ????????? ??????????? ???? ?????? ???????? ?????????? ??????????????? , ????????? ??????????????? ? ??????? .

??????? ???????? ???????? ????? ??? ?????? ???????????? ? ?????????????? ???????????, ? ??? ????? ??? ????????????? . ???????????? ??????????, ??? ? ??????????? ????? ??????? ???? ???????? ??????? ????? COVID-19 ? ?????????? ?????? . ????????, ??? ?????????? ???? ???????? ???????? ??????????? ? ?????? ????? ?????? ? ???, ??? ??????? ???? ?????, ?????? ??????? . ????? ?? ???????????????? ?? ??????? ????? ??????????? ????????????? ? ????? ? ????? ?????????? ???????? ???????. ????????, ??? ??????? ? ???, ??? ?????????? ??????? ????? ???????? ? ???????? ??????????? ????????????? ??????? ?????? (????). ???? ?? ???? ???? ??????????? ??????????? ???? ???????? ??????? ????? .

?????? ????? ???????, ??? ???????? ? 10 % ??????? ? ?????????? ????? ?????? ??????????? ?????????????? ???????? ? ???????????, ? 95 % ??????? ????? ??????. ???????????? ???????????, ??? ??? ???????? ????????? ?????? ??????????? I ????. ??? ? 3,5 % ??????? ?????????????? ??????? 13 ????????? ?????, ??????? ?????? ??????????? ???? ? ?????? ?? ??????? ??????. ? ????? ??????? ????????? ??????? ? ?????????? ? ??????? ?????? ?? 17 ?????? ?? ?????? ???????????? I ????, ?????????? ?????? ? ???????? ? ????? ?? ??????? .

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? ????? ??????????? ??????????? ??????? ??? ????????? ????????????? ???????????? Solidarity , ??????? ????? ??????? ????????????? ?????????? ????????? ??????? ?? ????????? ? ??????? ?????????????? ???????? . ?????????? ???????????? ? ???????? ????? 30 ????? ???? ???????????? ? ???? ????????? ? ???????? ???? ?????????????? .

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?????????? ??????????????? ??????? ???????????? ?????????? ?????????? ?????? ?? ?????-???? ?? ?????? ??? ?????????? ?????, ??? ???? ?? ????????? ???? ?????? ????????????? ????. ?????? ?????? ????????????, ????? ???????? ? ????? ????????????, ???????? ? ???????? ????? ?????????????????? ? ?????????? ? ????????. ?? ???? ??????? ?????????? ??????????????? ??????? ????? ?????????? . ??????? ??????????? ????????? ????????? ??????????????? ??????? .

???????? ???????????????? ?????? ?? ?????? 2022 ???? ????????? ???????????? ???????? ????? ???????? ??????????? ?????? ? ?????????, ?????? ?? ???? ?? ???????? ????????????? ?? ????? ???????? ?????????? .

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??????????? ? ????????? ???????? ?????????????????? , ?????????? ???????????-6 , ??????????? ??? ????????????????? ?????????? ? ? ??????? ???????????? ?????? . ? ?????? COVID-19 ???????????? ?? ??????????? ???????? ??????????? ??????? ???????????? ?????? ? ?????????? ????? ??????????. ?????? ??????? ? ?????????? ????????????????? ???????? ??????? ? ???????????? ???????? ??????????? ??????? ? ?????? ??????????? ?????????????????????? ???????? ? ??????????? ??????? ?? ????????????? ? ?????? ???????? ???????. ?????? ???????????? ?????? ???????????? ? ?????? ????????? . ??????????????? ?????? ? ????????? ??????????????? ?????? ??????? 21 ???????? ????????????? ???????????? ??????? ????????? ????????? ?????? ? ?????????? ??????? ????????? . ????????????????? ?????? ????????? ???????????? ????? ??????? ? ???????????????????? ??????????? ???????? ?????????? ????????????? ??? ? ???????? ??????????, ??? ? ? ?????????????? ?????????, ?????? ????????? ??????? ?? ????????? ? ??????? ??????? ???? . ?????? ??? ????????????????? ???????????? ???????? ????????? ???????? ?????? ????????????? ?????????? ?????? ? ?????? ?? ???? ??????? ???????????, ?? ?? ???????? ???????????? ??????????? ?? ???????? . ?????? ???????????? RECOVERY ????????, ??? ???????? ???????????? ? ?????????? ? ??????? ?????????????? ??????????????????? ????????? ?? ????????? ????????????? ??????? ???? ?????? ?? 14 %, ? ????????????????? ?????????? ????????? ? ???????? — ?? 5 ?????? ???? .

???????????

? ?????? ???????? ??????????? ???????????? ? ??????????????? ????????????? ????????????, ????? ??????? ?? ???????????? ?? ?????? ?????????????????? ????????????? ????????????, ? ????????? ???????????? ???????????? ????????? ???? ??? ?????????? ? ??????? ??????? ???????????. ?????????? ?? ?????? ????? ???????? ???????????? ?? ?????????? ??????????? ????? ????????? ? ?? ????????? ?????? ?????-???? ?????? ? ??????????? ??? ??????????. ??????????? ????? ? ???? ?? ????????????? ? ??????????, ?? ??????????? ?????????????? ????????? .

?????? ?????????????

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?????????????? ???????? ???????????? ????? ????????????? ?????? ????????? ???????????, ??? ????? ??????????? ? ??????????? ??????? ??????, ??????????? ??? ? ??????????? ??? ????????? ? ?????? ????????? . ? ?? ????? ??? ??????? ???????? ?????? ????????? ????????????, ?????????????? ???????? ????? ????????? ????????? ??? ???????????? ???????? ????? ?????????, ????????, ? ???????, ????? ???????? ?????? ? ?????? ????? ? ?? ???? ?????????????, ??? ???? ??? ???????? ? ?????? ????? ??????????, ????? ????????? ??? ?? ????? ??????????????. ??????????? ?????????????? ??????? ???????? ??, ??? ??? ????? ???? ???? ????????? ?????? ? ???????? ? ???????????? .

????? ????? ????? ? ?????? ? ????????????? ???????, ????? ????? ???? ??????????????, ??? ??????????? ?????????? ?????????????? ???????. ? 2021 ???? ?????????????? ???????????/????????? , ? 2022 ???? ? ????????????? ????????? ?????????????? ???????? — ?????????? .

???????? ?? ???????????????

COVID-19 ????? ???????? ????????? ?????????, ????????? ? ?????????????? . ?????????????? ???????????? ? ??????? ? ?????????????? ???????? ????????? . ??? ????????????? , ????????? ? COVID-19, ????? ????????? ??????? ??????????????? , ???? ????? ???????????? ??????? , ??? ???? ??????? ?????????? ? ?????????-?????????????? ??????????????? . ????????? ??????????? ??????? ???????????????? ????? ????????? ? ?????????????, ???? ?????????????? ????????? ??? ?? ???? ?? ???????? ??????????? ??? ????????????? ??????? ???? ???????. ???????????? ??????????? ????????? ? ???????? ?? ?????????? ?????? ? ????? ??????????? ?????????? ???? ?? ?????, ? ??? ????? ?? ???????????? ??? ???????, ?????? ? ????? ???????? ???????? — ? ????????????? ???????????? ????????????????? ????????? ??? ??????????? ?????????? ????????? ? ??????? COVID-19 . ??????????????? ?????? 2773 ????????? ? COVID-19 ??????? ???????????? ???????? ???????????????? ?????????? ????? ???????, ??????? ??????????? ???????????? ?????????? ??????, ???? ?? ??????????? ??????? ???????????????? . ????????????????? ???????????? REMAP-CAP ???? ???????? ?????????? ? ???????? ???????? ?????????? ??? ????????? ? ??????? ??????????, ??????? ??????????? ??????????? ???????: ??????? ???????????????? ?? ?????? ?? ??????, ?? ????????? ? ????????????? .

????????? ??????????? ?????????? ???????????? ?????????????? ??? ???????????? ????????????????? ????? ????????? ? COVID-19, ?????? ?? ????????? ?? ?????? ??????? ???? ???????????? ????????????? ??? ??????????? ??????????? ????????? ?????? ? ?????? ????? ??????????????????? ????????? .

????????? COVID-19 ? ???????

?????? ?????? ? COVID-19 ???????????????? ??????? ???????, ???????????? ??? ?????, ??????? ??? ?????????, ????? ???? ????? ????? ??????? ? ??? ??? ??? ??????????? ?????????? ????? ??? ????? ??????? ? ?????? ?? ?????, ??? ???????? ?? ????????? ????? ????? ???? ??????? ????? ?????????? ????? ??? ??????????? ????????????? ? ????, ??? ??? ?????? . ? ?????? ?????? ?????? ???? ?????? ??????????????? ??????? ????? ?????, ? COVID-19 ????????, ?????? ?????, ????????, ?? ??????? ??? ?????????? ????, ??? ?????????? ??????????????? ?????? ???????????? ????????? ???????????? . ??????????? ??????????? ?? ?????????????? , ??? ???????? ?????? ?? ?????? ???????? ?????????? ???????? 1,3 ???????? ( ?????? ??????????? R = 1,28), ??? COVID-19 ??????? ?????????????? ??????????? ?? 2—2,5 ???????? .

???????? ? ??????????? ??????, ?? ??? COVID-19 ????? ????????? ?????? ???????? ??? ?????, ??? ?????? ?? ?????? ???????? ??? ????? ?????? ?? ??????????. ???????? ? ???????? ????? ???? ??? ????? ????????????, ?? ??? ?????? ??? ????? ???????? ? ????????????? ? ??????????. ??? COVID-19 ???????? ?????????? ??????? ????????? ???? ??? ????????????? ??????? ??????????? .

??? ??????????? ????? ????????? ??? ? ??????, ??? ? ? ??????? ?????, ?????? ??????? ? ??????????? ??????? . ??? ????? ???????????? ???????? ????????? ??????????, ??????? ?? ????????? ? ??????????? ??????????????? ? ?????????? ???????????? ???????????????? ? ????????, ?? ? ?????? COVID-19 ????? ?????????????? ??????? ? ????? ? ???????? ??????, ??????, ??? ? ?????, ? ? ????? ???? ???? ????????????? ???????????????? ??????????????? ????????. ? ??????? ????? ??????????? ? ??????? ????? ????????? ??????? ???? ? ???? ? ?????????????? ?????????????, ?? ??? ?????? ? ?????? ????? ????? ?????? ???? . ?????? ????????? ?????? ??? COVID-19 ???? ???? ?????????? ?????? ???????, ????? ??????? ?? ?????????? ?????????? ?????, ???????? ????? ?????????? ??????????? ? ???????????, ????????? ??????????? ??????? . ? ??????? COVID-19 ???? ?????????????? ? ?????? ????, ??? ??? ??????, ???????? ? ?????, ???????? ? ?????? ????? , ? ????? ???? ??????? ?? ??????? ??????????????? .

? ????? ??????? ??????? ?????????? ?? ?????????? ?????????, ? ? ??????? ??????? ????? ????????????? ?????????????? ? ?????????????? ???????, ????????, ???????????? ?????????? ?????? . COVID-19 ??????? ???????? ?????????? ? ???????, ?????? ??????????????? ??????? ?????? ??????????, ??? COVID-19 ??????? ?????? ??? ??????????????????? ????????? .

????????????

11 ??????? 2020 ???? ????????? ??????????? ?? ??????????????? ???? ??????????? ??????????? ???????? — COVID-19 . ????????????, ?????????? ????????, ???????? ?????? ? ????? ??????????? ??????????? ?????????? ???????????????, ???????? ????????, ????????????, ??????? ??????????? ? ??????? ??????? . COVID-19 — ?????????? ?? « CO rona VI rus D isease» — «???????????, ????????? ?????????????». ? ???? ???????? «??» ???????? «??????» (corona), «VI» — «?????» (virus), «D» — «???????» (disease), ? «19» — ???, ? ??????? ???? ???????? ??????? ??????????? (???????? ? ??? 31 ??????? 2019 ???? ).

????? ??, ?????????? ???????????, ?????????? ??-??????? — SARS-CoV-2. ????? ???????? ????, ????????? ????? ??????????? ???? ? ??????? SARS-CoV, ??????? ? 2003 ???? ??? ???????????? ?? ??????? ???????? ??????? ?????????????? ???????? ? ?????. ?????? ????? ???????????? ???????????? «????? COVID-19», «?????????????? ???????? COVID-19» ??? «?????, ?????????? COVID-19». ??? ?? ????? ???????? ??????????? ?? ???????? ????????? ?????? ? ?? ????????????? ??? ????????? ???????? SARS-CoV-2, ??????? ????????????? ????????? ?? ?????????? .

? ??????? ????? ????? ????????????? ???????? « » . ??? ????? ?????????? ?? ?????? ????? ????????, ???????? ???????? ???????????????? ??????????????? ?? ????? ?????? ????? ????? «???????????» ??? ??????????? ??????????? . ???????????? ????? «?????» ??????? ? ???????????????? ? ?????????? ????? ????, ??? « », « », « » ? « » . ???????? ?????? ???????? ????????, ??? ???????? ?? ?????????? ????? ? ???????? ?????? ??????????, ??? ????? ????????????, ?????????????? ?????? , ?? ???? ?????????????????? .

?????????????

????? ?????????????? ??????? COVID-19 ???????????? ? ????????????? ???????????? ?????????????, ?????????, ????????????, ??????? ? ?????? ???????? ??????????? ?????? ???????????????? ? ????????? . ????????????? ????? ?????? ???????????? ??????. ?????????? ???????????? ?????? ??????? ? ??????????? ?????????? ????? ????????? ????????? ?? ???????????, ? ???????? ?? ??????????? ????????? ????? ?? ?????????? ???????????? ?????, ? ????? ????????? ????????????? . ????? ?? ????? ???????? ????????? ???????? ?????-?????????????. ?????-???????????? ???????? ?????, ??????? ?? ????? ? ????????????? ?????? ??? ?????? ???????????? ?????????? ????????. ????? ???? ????? ?? ?????? ?????, ?? ????????? ????????? ??? ??????????? ?????????????, ? ??? ??????????? ?? ????? ?????????? ? ??????. ???????? ??????, ????? ????? ???? ???????????? ?????? ? ?????????? ??? ???? ??? ??????, ?? ??? ?????? ?? ????? ???????? .

???????? ???????? ? ?????? ? , ?????????????? ? ??????? ?????? ??????????????? ?????? ? ???????? ?????????? ????? ????????? ?????????? ????? . ? ?????????? ????????? ??? , ??? , ?????? ? ?????? ??????????? ???????? ??????-????? ??? ??????????? ? ??????????? ????? ?? ??????????????? ??????????????? ????????? ????? ?????????????? ??????????????? ?????? ??????????, ?????????? ?? ??????? ?????? ? ???????????????, ????? ???? ?????????, ???????? ????? ?????, ???????? ? ?????? ?????, ? ????? ????? ?????? ? ??????????????, ???????? ??? ???? ???????? ? ??????? ????????? ?????? .

??. ?????

??????????

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????????	??????? 5 ????? ???? ????? ?????? ???????
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????????

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??????? ??????????? ? ??? ????????

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??????????????????? COVID-19

?????????????? ??????? ? ????????????

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Same as COVID-19

Распространение COVID-19 в ДНР

К удалению/3 июня 2020

NN21

Пандемия COVID-19

Распространение COVID-19 в Санкт-Петербурге

Распространение COVID-19 в Великобритании

Вакцина против COVID-19

Южный Парк: После COVID’а: Возвращение COVID’а

Распространение COVID-19 в Суринаме

Распространение COVID-19 в Непале

Конспирологические теории о пандемии COVID-19

Распространение COVID-19 в Белоруссии

К удалению/4 февраля 2022

Рецессия в связи с пандемией COVID-19

Распространение COVID-19 в Бельгии

Распространение COVID-19 в Гвиане

Распространение COVID-19 в Пакистане

Распространение COVID-19 во Франции