Interested Article - Аутофагосома

???????????? ???????????? ????? ??????????? ????????? ? ???????????? ??????????. ??? ???????? ????????? ?????????????? , ??????? ??????????????? ?????????? ??????????????????? ??????????? (????????, ?????????? ??????????????? ??????, ?????????? ??? ???????????? ????????, ????????? ???????????????). ????? ??????????? ???????????? ?????????? ?????????????????? ?????????? ? ????????? . ???????? ???????? ???????????? ????????? ? ?????????, ??????? ???????????? . ????????? ??????? ????????? ?????????? ???????????? ? ?? ?????????? ????????.

??????????? ??????????? ???????????? ??????, ?????? ??????????? ?? ??????? ?? ?????? ????????. ???????????? ???? ????? ???????? ?? ?????? ? ??????, ?? ? ????????? ???? ??? ???????????. ????????? ?????, ????? ????????? ??? APG, AUT, CVT, GSA, PAZ ? PDD, ?????? ?????????? ? ????????? ATG (????????? ? AuTophaGy).

?????? ??????????? ? ????????????? ? ??????? ???????????. ????????? ???????????? ?????????? ????? 500-900 ??, ????? ??? ???????????? ????????????? ??????? (500-1500 ??). ? ????????? ???????? ??????, ????? ??? ????????????? ????????? ?????? , ????????????? ??????????? ? ?????????? , ???????????? ????? ??? ???????? ??????????? ? ????? ???? ????? ??? ?????????????? ?????????.

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????????? ???? ??????????????? ??????????? ????????? ?? ?????????????????? ?????????? ? ??????????? ?????????? ????????, ?????????? ??????????.

??????????? ??????????? ?????????????? ?????? Atg ????? ????????? Atg12-Atg5 ? LC3. ???????? Atg12-Atg5 ????? ??????????????? ? Atg16 ? ???????????? ????? ??????? ??????????. ??????????? Atg5 ? ??????? Atg12 ?????????? ??? ????????? ???????? ????????.

????? ??????????? ??????????? ????????? ???????? ATG12-ATG5:ATG16L1 ???????????? ?? ????????????. LC3 ???????????? ????????? ATG4 ? ???????????? ???????????? LC3. ??????????? LC3 ?????????? ??? ????????????? ??????? ???????????? ? ?????????-???????. LC3 ?????? ???????????? ? ???????? ??????? ??????????? ? ???????????????, ????????? ?? ???????? ???????????? ?????? ???????? ? ???????? ??????????????? ?? ?????????? ??????? ????? ?? ????????. ??????? ???????????? ????????? ? ?????????? ??? ?????????? ??????????? ?????????????. ??? ????????? ?????????? ?????????? ??? ?????????????? ??????????????? ?????????. ??? ?? ?????, ??? ????????? ???????? ???????????? ??????? ???? ????????? ????????????? ??????, ????? ??? ???????? D.

??????? ?????????? ? ???????, ?????? ???????? ????? ???????????. ????????, LC3 ? ????????????? ???????????? ????? Atg8 ? ???????, ? ???????????? ?????????? ?? ????????????????? ????????? (PAS), ??????? ?????????? ?? ????????-???????????????? ? ??????? ?????????????. ????????????????? ????????? ? ??????? ??????????? ??? ????????, ?????????????? ?????? ???????. ?????? ???????? ???? ??????????? ??????????. ?????? ????????? ???????????? ????????? ??????????????? ? ????????? ??? ?????????? ? ?? ???????? ???????, ??? ? ?????????????.

? ?????????? ????????? ???????????? ????? ????????? ?????? ????????? ????, ????? ??? Atg1, Atg13 ? Atg17. Atg1 ???????????? ????? ??????, ?????????? ??????? ?????????? ??? ???????? ?????????. Atg13 ?????????? Atg1, ? ?????? ??? ???????? ????????, ?????????? Atg13:Atg1, ??????? ???????? ??????? ?? ??????? ?????????? ??????????? ??????? — Tor. Atg1 ????? ????? ?? ??????? ??????? ???????????? ???????????.

??????? ? ????????

? ???????? ???????????? ???????????? ?? ???????? ???????? ? ????????? (???????????) ?? ???? ??????????? ? ???? ?????? ????? ?????? . ???? ??????????? ????????? ??????????, ???? ?????????? ??? ??? ????????????????? ??????? HAP1, ??????? ???????????? ????????? ? ?????????????? ? ????????, ????????.

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