Interested Article - Митотический кроссинговер
delana
- 2021-12-19
- 2
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???????? ???????????? ???????????? ???? ????????? ?????? ??????? ? 1936 ???? ? ?????????? ???????????? ???????? , ?????????? ?????????????? ?? ???? ?????, ??????????? ?? ????? ?-????????? ? ???????????? ????? ?????????????? ????????: ???? ???? ? ????? ???????. ??????????? ?????? ??????? ???? y ????? ?????? ??????? ????, ??????????? ?????? sn (singed) — ????????? ???????. ??????????? ?????????????? ? ????????? y+//+sn ????? ????? ??????? ?? ????? ?????????, ?????? ??????? ?? ???? ????????? ??? ?????????? ??????? ?????. ? ????? ????? ???? ???????? ???? ?????? ? ? ??????????? ????????? (??????????? ???????), ? ?????? — ??????????? ?????? ????? (??????????? ???????), ?? ? ?????????? ?????????. ???????? ????? ???? ??????? ???????? ??? ? 1925 ???? , ?? ???? ??????? ???? ????? ???????? ?? ????????? ???????????? ?????????????? ?? ?????? 4-? ???????? .
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???????????? ???????????? ????? ??????????? ? ????? ?????? , ?????? ?? ????????? ????? ???? ?????, ????? ????? ????????????? ?? ???? ???????. ? ?????????? ????????????? ????????????? ??? ??????????? ???????? ? ???????? ??????? ?????? ?????????????? ??????? ?????, ??? ??? ? ???? ??????? ?? ??????? ???? ?? ???? ???????? ????? ??????????, ? ?????? — ??????????????.
????? ???????, ??????? ???????? ?????? ??????? ?? ????, ??? ?????????? ????????? ?? ?????????? ????????? . ???? ??? ?????????????? ?????????, ?????????? ????????? ?????? , ??????? ?? ????????? ???? ?????? ?????, ?? ???????? ?????? ????? ?????????????? ? ? ?????????? ?????????, ???????? ?? ???????????? (??? ??? ?????????????? ??????? ??? ?? ??????? ???????????? ???? ?????). ???? ?? ?????? ?????????????? ????????? ?????? ??????????, ?? ?????? ????? ???????????? ?? ??????????????? ??????. ??????????? ????? ????? ????????? ???????? ?????, ??? ? ????????? ?????? ????? ??????????? ???????????? ??????????? ???????, ? ? ?????? — ???????????? ??????????? (?????) ???????. ???? ????? ???????? ?????? ????????? ???????????? ? ???????? , ??????? ????? ????? ?????, ??????? ? ????????? ????? ?????????.
???????????? ???????????? ?????????? ? ??????? ????????? . ???? ????????? ?????????????, ??? ???????????? ?????????? ? ??????? G 1 -???? , ????? ????????? ??? ?? ??????? . ? ????? ???????? ????? ???? ????????????, ??? ???????????? ???????????? ?????????? ?????????? ????????? ????? ???????????? ???????????? ?????????? ??????????? ???, ? ??? ??????? ???? ? G 1 -????, ?????? ????? ???????????? ??, ??? ????????? ????? ???????????? ???????????? ?????????? ? ???????? ????? ?????????? .
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???????????? ?????????, ?????????????? ???????????? ????????????, ????? ? ???????????? ? ???????????? ????????????? . ? ??? ?????????: ??????????? ??????????????? , ???????????? ????????????, ???????????? ??????????? ????????? ???, ??????????? ? ???????? ???????? . ???????? ?????, ???? ? ? ??????????? ????? ?????? ????????????, ??????? ?????????? ????????? ??????????? ??? ????? ?????????????? ???????????? .
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?????????? ????????? ??????, ???????????, ??? ?????????? ???????????? ????????????. ? ?????????? ?????? ????????????? ??? ????????? ????????????? ??? ?????????? ? ?????????????? ?????? ?????? , ??????? ??????????????? ? ????????. ??? ????????????? ?????????????? ??????? ? ?????? ????? , ?? ??????????? ????? ????????? ?? ?????? ????? ?? ???? ??????????? ???????? ?????? ?????????. ??? ????????? ???? ?????????? ???????????? ?????????. ? ?????? ?????? ??? ??????????????? ????????? ???????? ????????? ???????? ?? ????? ????????????? ???????. ????? ??? ?????????????? ????????? ??????????? ???, ??? ???? ????????? ???????????? ???????? ????? ?? ???????? ? ???????? ????????? ?????? ???????????? ?????????. ? ????? ??????? ???????????? ???????????? ???????? ???? ?? ????? ?? ????????? ???????.
? ?????? ???????, ???????????? ????? ??????????? ? ???? ????????? ??? , ???? ????????? ????????? ???????? ??? ????????? ???????????? ???????????? ?????????.
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???????????? ???????????? ????????? ? D. melanogaster , ? ????????? ?????????????? ???????? ????? ?????? ? ? ???????????? ??????? ???????? ? ????. ? ????????? ?????? ???????????? ???????????? ????? ????????? ? ????????? ??????, ??????????????? ??????????? ????????????? ???????, ?????????????? ? ???????? ????. ? ?????? ???????, ?????? ????? ????? ? ???????????? ???????? ?? ????-?????????? ??????????? ?????, ??? ???????? ? ???? ?? ?????? ?????????? . ????????, ??????? ????? ?????????? ???????? , ??????? ?????? ???? ? ?????????? ? ????????? ???. ? ????? ??? ??????? ????? ? ????????? ??????? ???????????? ????????????, ??? ? ???? ??????? ???????? ??????? ???????? ???????? .
? ?? ?? ????? ???????????? ???????????? ????? ????? ? ????????????? ?????? ??? ?????????, ? ???????? ??????????? ?????? ? ???????????? ????????? ????? ?????????????, ??? ? ?????????????? .
??? ????????????? ? ???????? ????????? ??????????, ????????, ?????????, ???????????? ???????????? ????? ??????? ???????????? ????????????? ?????????? ? FLP-FRT-????????????? .
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- ? Hartel, Daniel L. and Maryellen Ruvolo. Genetics: Analysis of Genetics and Genomes (????.) . — Burlington: , 2012.
- ? Tischfield, Jay A. Loss of Heterozygosity, or: How I learned to Stop Worrying and Love Mitotic Recombination (????.) // : journal. — 1997. — November ( vol. 61 , no. 5 ). — P. 995—999 .
- Stern, Curt. (????.) // Genetics : journal. — 1936. — Vol. 21 , no. 6 . — P. 625—730 .
- ????-???????? ?.?. ???????? ? ???????? ????????: ??????? ??? ????????? ?????? ??????? ????????? / ?. ?. ????-????????. — ???. : ???-?? ?-?, 2010. — ?. 193—194. — 720 ?. — ISBN 978-5-94869-105-3 .
- Esposito, Michael S. Evidence that Spontaneous Mitotic Recombination Occurs at the Two-Strand Stage (????.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1978. — September ( vol. 75 , no. 9 ). — P. 4436—4440 .
- ? LaFave, MC; J Sekelsky. Mitotic Recombination: Why? When? How? Where? (????.) // : journal. — 2009. — Vol. 5 , no. 3 . — doi : .
- Helleday, Thomas. Pathways for Mitotic Homologous Recombination in Mammalian Cells (????.) // : journal. — Elsevier , 2003. — Vol. 532 , no. 1—2 . — P. 103—115 .
- Pâques, Frédéric; James E. Haber. Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae (????.) // : journal. — , 1999. — Vol. 63 , no. 2 . — P. 349—404 .
- Helleday, T. . Animation . MIT. ???? ?????????: 1 ????? 2013. 23 ????? 2013 ????.
- Helleday, Thomas. (????.) // Mutation research : journal. — 2003. — November ( vol. 532 , no. 1—2 ). — P. 103—115 . 24 ??? 2014 ????.
- Luo, Guangbin; et al. Cancer predisposition caused by elevated mitotic recombination in Bloom mice (????.) // Nature Genetics : journal. — 2000. — Vol. 26 . — P. 424—429 .
- Xu, T; GM Rubin. Analysis of genetic mosaics in developing and adult Drosophila tissues (????.) // Development : journal. — 1993. — April ( vol. 117 , no. 4 ). — P. 1223—12237 .
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- Griffiths et al. 1999. . W. H. Freeman and Company.
- ????-???????? ?.?. ???????? ? ???????? ????????. — ???. : ???????????? ?-?, 2010. — ?. 193—194. — 718 ?. — ISBN 978-5-94869-105-3 .
delana
- 2021-12-19
- 2
