Interested Article - Оротовая кислота

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???????? ??????? ???? ??????? ? 1904 ???? Biscaro ? Belloni; ??????? ???????? ? 1905 ???? ?? ????????? ??????, ????? ??????? ? ?????? ?????? ????????, ? ??? ????? ? ? ??????? .
? 1930 ???? Bachstez ?????? ?? ?????????.
? 1947—1948 ??. Mitchell ? ??? ???????? ??????????, ??? ???????? ??????? ???????? ????????????? ????????? ?????????? ????????????? ??????????? ? ?????? ? ?????? ???? ????? ??????.
? 1948 ???? ??? ?????? ?????? ????? ???? ? ??????. ??? ??????? ??????? B13.
? 1953 ???? Manna ? Hauge ????????, ??? ??????? B13 ? ???????? ??????? — ?????????? ???????? .
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?? 3 ??????? 2016 ?? Wayback Machine / The EFSA Journal (2009) 1187, 1-25 (????.) : "The Panel concludes that in the light of the tumour-promoting effect of orotic acid in animal experimentation, the small margin of safety to this effect from foreseeable exposure, and the absence of any relevant studies on genotoxicity and of any developmental studies, the use of orotate as a source of the eight other minerals and choline at the proposed levels of use is of safety concern".